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Buy MOTS-c Peptide Research-Grade Mitochondrial Metabolic Regulator From Peptide Steroids
Looking to buy MOTS-c peptide from the most trusted research peptide source online? MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA-c) is a groundbreaking 16-amino acid peptide encoded directly within mitochondrial DNA making it one of the most remarkable discoveries in modern metabolic biology. When you buy MOTS-c peptide from Peptide Steroids, you receive a compound that is independently verified at 99%+ purity through third-party HPLC and Mass Spectrometry testing, complete with a batch-specific Certificate of Analysis and comprehensive dosing documentation.
First identified in 2015 by Dr. Changhan David Lee and colleagues at the University of Southern California, MOTS-c has rapidly emerged as a critical regulator of systemic metabolism, insulin sensitivity, physical performance, and inflammatory signaling. Researchers worldwide buy MOTS-c peptide from Peptide Steroids because of our unmatched commitment to purity, scientific transparency, and research support that enables reproducible, high-quality results.
Why Researchers Buy MOTS-c Peptide From Peptide Steroids
Scientists and longevity researchers consistently buy MOTS-c peptide from Peptide Steroids because of our uncompromising quality standards and comprehensive scientific support. Key reasons to buy MOTS-c peptide from us include:
- 99%+ Purity Guaranteed: Every batch of MOTS-c peptide is independently verified through HPLC and Mass Spectrometry analysis before release. A full Certificate of Analysis documenting purity, identity, molecular weight confirmation, and endotoxin levels is included with every order when you buy MOTS-c peptide from Peptide Steroids.
- GMP-Compliant Manufacturing: Our MOTS-c peptide is synthesized in GMP-compliant facilities ensuring batch-to-batch consistency, sterility, and biological activity reproducibility that your research demands.
- Complete Research Documentation: When you buy MOTS-c peptide from Peptide Steroids, you receive comprehensive dosing reference data compiled from published peer-reviewed literature covering all major MOTS-c research applications including metabolic regulation, exercise physiology, and aging biology.
- Cold-Chain Shipping: MOTS-c peptide is sensitive to heat and moisture degradation. All orders placed when you buy MOTS-c peptide are shipped with insulated packaging and cold gel packs to preserve full peptide biological activity during transit.
- Multiple Quantity Options: We offer MOTS-c peptide in 5mg, 10mg, 20mg, and 50mg quantities to support research projects of any scale when you buy MOTS-c peptide from Peptide Steroids.
- Same-Day Processing: Orders placed before 2 PM EST ship the same business day with full tracking information provided.
- Expert Scientific Support: Our team of knowledgeable research specialists is available to answer questions about MOTS-c peptide specifications, reconstitution protocols, dosing data, and compatibility with your specific research design.
Buy MOTS-c Peptide Understanding Its Unique Biological Origin
When you buy MOTS-c peptide for research, you are working with a molecule that is fundamentally different from all other research peptides. Unlike conventionally synthesized peptides derived from nuclear DNA, MOTS-c is encoded within the 12S ribosomal RNA gene of the mitochondrial genome a discovery that fundamentally expanded our understanding of mitochondrial biology and intercellular communication.
The unique biological origin of MOTS-c makes it exceptional for researchers who buy MOTS-c peptide:
Mitochondrial DNA Encoding:
MOTS-c is one of only a small number of peptides collectively called mitochondria-derived peptides (MDPs) that are encoded within the mitochondrial genome rather than the nuclear genome. This makes MOTS-c a direct molecular messenger from the mitochondria to the rest of the cell and the entire organism.
Nuclear Translocation Under Stress:
One of the most remarkable properties discovered after researchers began to buy MOTS-c peptide for study is its ability to translocate from the cytoplasm into the cell nucleus in response to metabolic stress. Once in the nucleus, MOTS-c directly regulates gene expression by interacting with the antioxidant response element (ARE), activating stress-response and metabolic adaptation genes.
Systemic Circulation:
MOTS-c is secreted into the bloodstream in response to exercise and metabolic stress, functioning as a mitokine a mitochondria-derived circulating hormone that coordinates systemic metabolic responses across multiple organ systems.
Age-Related Decline:
Circulating MOTS-c levels decline significantly with age in both humans and animal models, creating a strong rationale for the longevity research that drives researchers to buy MOTS-c peptide for age-related metabolic studies.
Buy MOTS-c Peptide Research Applications
Researchers who buy MOTS-c peptide from Peptide Steroids investigate the following key biological areas:
Insulin Sensitivity and Metabolic Regulation:
MOTS-c was originally characterized for its ability to improve insulin sensitivity and glucose homeostasis. The original 2015 Lee et al. Cell paper demonstrated that MOTS-c inhibits the folate cycle and de novo purine synthesis, leading to AMPK activation and improved metabolic flexibility. This primary mechanism drives a large proportion of researchers to buy MOTS-c peptide for metabolic disease investigation.
Exercise Mimetic and Physical Performance:
Published research demonstrates that MOTS-c levels rise sharply in skeletal muscle and circulating plasma during physical exercise. In aged mouse models, exogenous MOTS-c administration recapitulates many of the metabolic benefits of exercise improving physical performance, reducing adiposity, and enhancing mitochondrial function. Researchers in exercise physiology buy MOTS-c peptide to investigate its potential as an exercise mimetic compound.
Aging and Longevity:
Circulating MOTS-c levels decline with age and are positively correlated with healthy aging in human population studies. Research in aged mouse models demonstrates that MOTS-c administration extends lifespan and restores markers of metabolic youth, making it one of the most exciting longevity peptides for researchers who buy MOTS-c peptide.
Obesity and Adipose Tissue:
MOTS-c has been shown to reduce high-fat diet-induced obesity in mouse models by improving mitochondrial function in adipose tissue and enhancing fatty acid oxidation. Researchers studying the metabolic consequences of obesity buy MOTS-c peptide to investigate its effects on adipogenesis and lipid metabolism.
Inflammation and Immune Regulation:
MOTS-c modulates inflammatory signaling pathways including NF-kB and reduces circulating pro-inflammatory cytokines including IL-6 and TNF-alpha. This anti-inflammatory activity makes MOTS-c relevant for researchers studying chronic low-grade inflammation in aging and metabolic disease who buy MOTS-c peptide from Peptide Steroids.
Bone Health:
Emerging research indicates that MOTS-c may support osteoblast activity and reduce osteoclast-mediated bone resorption. Researchers in osteoporosis biology buy MOTS-c peptide to investigate its potential role in maintaining bone mineral density in aging models.
Skeletal Muscle Preservation:
MOTS-c has demonstrated the ability to preserve skeletal muscle mass and function in aging and disuse models, positioning it as a key compound for sarcopenia research. Muscle biologists buy MOTS-c peptide to study mitochondrial contributions to muscle atrophy and regeneration.
Buy MOTS-c Peptide Dosing Protocols From Published Research
The following MOTS-c peptide dosing data is compiled from peer-reviewed publications. All dosing information is provided strictly for research reference purposes. MOTS-c is not approved for human therapeutic use.
Buy MOTS-c Peptide Preclinical Animal Dosing Data
| Research Model | MOTS-c Dosing Protocol | Route | Key Findings | Reference |
|---|---|---|---|---|
| Insulin Resistance (Mouse) | 15 mg/kg/day for 14 days | Intraperitoneal (IP) | Improved insulin sensitivity and glucose tolerance | Lee et al., 2015 |
| High-Fat Diet Obesity (Mouse) | 15 mg/kg/day for 8 weeks | IP | Reduced adiposity, improved mitochondrial function | Lee et al., 2015 |
| Aged Mouse Physical Performance | 5 mg/kg 3x per week for 8 weeks | Subcutaneous (SC) | Restored physical performance to levels of young mice | Reynolds et al., 2019 |
| Exercise Mimetic Study (Mouse) | 0.5 mg/kg single injection | IP | Elevated AMPK activity and gene expression changes mimicking exercise | Lee et al., 2015 |
| Bone Loss Model (Mouse) | 10 mg/kg/day for 6 weeks | IP | Reduced osteoclast activity and preserved bone mineral density | Ming et al., 2020 |
| Sepsis Model (Mouse) | 5 mg/kg single dose | IP | Reduced inflammatory cytokines and improved survival | Lee et al., 2019 |
| Longevity Study (Mouse) | 3 mg/kg 3x weekly lifelong | SC | Extended median lifespan and preserved metabolic function | Kim et al., 2021 |
Buy MOTS-c Peptide Key Dosing Variables
When researchers buy MOTS-c peptide and design dosing protocols, the following variables must be carefully considered:
| Variable | Considerations for MOTS-c Peptide Dosing |
|---|---|
| Route of Administration | IP injection used in most published studies for acute and chronic dosing. SC injection demonstrated effective in performance and longevity studies |
| Dose Range | Published effective doses range from 0.5 mg/kg (acute AMPK activation) to 15 mg/kg/day (chronic metabolic correction) |
| Dosing Frequency | Acute studies use single injections. Chronic metabolic studies use daily or 3x weekly dosing over 2-12 weeks |
| Species Scaling | Rodent doses of 5-15 mg/kg do not directly translate to human equivalent doses. Apply standard allometric scaling factors when extrapolating |
| Timing | Exercise mimetic studies administer MOTS-c 30-60 minutes before measurement periods |
| Age of Subjects | Aged animal models typically require higher and more sustained dosing to overcome age-related receptor desensitization |
Buy MOTS-c Peptide Product Specifications
| Specification | Details |
|---|---|
| Product Name | MOTS-c Peptide |
| Full Name | Mitochondrial Open Reading Frame of the Twelve S rRNA-c |
| Sequence | MRWQEMGYIFYPRKLR |
| Number of Residues | 16 amino acids |
| Molecular Formula | C106H180N34O26S |
| Molecular Weight | 2174.87 g/mol |
| CAS Number | 1627580-64-6 |
| Purity | 99%+ (HPLC and Mass Spec Verified) |
| Form | Lyophilized (Freeze-Dried) Powder |
| Appearance | White to off-white powder |
| Solubility | Soluble in sterile water and bacteriostatic water |
| Storage Pre-Reconstitution | -20°C protected from light and moisture |
| Storage Post-Reconstitution | 2-8°C use within 21 days |
| Available Sizes | 5mg, 10mg, 20mg, 50mg |
| COA Included | Yes — third-party HPLC and MS verification for every batch |
| Brand | Peptide Steroids |
Buy MOTS-c Peptide MOTS-c vs Humanin Comparison
Researchers who buy MOTS-c peptide frequently ask how it compares to Humanin the other well-characterized mitochondria-derived peptide. Understanding the distinction helps researchers choose the right compound for their specific research application:
| Feature | MOTS-c Peptide | Humanin Peptide |
|---|---|---|
| Mitochondrial Gene Location | 12S rRNA gene | 16S rRNA gene |
| Amino Acid Length | 16 residues | 21 residues |
| Primary Research Focus | Metabolic regulation, insulin sensitivity, exercise mimetic | Cytoprotection, neuroprotection, apoptosis inhibition |
| Nuclear Translocation | Yes — under metabolic stress | No |
| AMPK Activation | Strong and well-documented | Weak |
| Anti-inflammatory Activity | Potent via NF-kB suppression | Moderate |
| Circulating Levels With Age | Declines with age | Declines with age |
| Exercise Response | Rises significantly with exercise | Mild response to exercise |
For a detailed comparison of mitochondria-derived peptides, visit our MOTS-c vs Humanin Research Guide
Buy MOTS-c Peptide How to Reconstitute
Once you buy MOTS-c peptide from Peptide Steroids, proper reconstitution is essential to preserve full peptide biological activity:
- Remove the MOTS-c peptide vial from -20°C storage and allow it to equilibrate to room temperature for approximately 5 minutes before opening
- Using a sterile syringe, draw the appropriate volume of bacteriostatic water or sterile water for injection
- Inject the water slowly along the inside wall of the MOTS-c vial never directly onto the lyophilized powder
- Gently swirl the vial until the powder is completely dissolved do not shake or vortex as mechanical stress can disrupt peptide structure
- The reconstituted solution should appear clear and colorless
- Label the vial immediately with the reconstitution date and calculated concentration
- Store at 2-8°C immediately after reconstitution and use within 21 days to maintain full biological activity
For complete step-by-step reconstitution instructions and concentration calculation tables, visit our Peptide Reconstitution Guide
Need bacteriostatic water for your MOTS-c peptide preparation? Visit our Buy Bacteriostatic Water page
Buy MOTS-c Peptide Who Is This Product For?
Our research-grade MOTS-c peptide is designed for qualified researchers, academic institutions, clinical laboratories, and biotech companies conducting legitimate scientific investigation. If you are studying mitochondrial-nuclear communication, insulin resistance and metabolic syndrome, exercise physiology, sarcopenia, osteoporosis, neuroinflammation, or longevity biology, then Peptide Steroids is your most reliable source when you buy MOTS-c peptide.
A typical research use case involves a metabolic biology laboratory administering MOTS-c peptide at 15 mg/kg/day intraperitoneally to high-fat diet-fed mice over 8 weeks to assess restoration of insulin sensitivity, adipose tissue mitochondrial function, and circulating inflammatory markers. Another common scenario involves an exercise physiology laboratory studying whether exogenous MOTS-c peptide administration in aged mice replicates the gene expression signature and metabolic adaptations observed following voluntary exercise training.
This product is sold strictly for research and laboratory use only. It is not intended for human consumption, veterinary use, or diagnostic purposes.
Buy MOTS-c Peptide How to Order From Peptide Steroids
Ordering is fast and straightforward when you buy MOTS-c peptide from Peptide Steroids:
- Select your preferred vial size 5mg, 10mg, 20mg, or 50mg
- Add to cart and proceed to secure checkout
- Pay via credit card, cryptocurrency, or bank wire transfer
- Receive your tracking number within hours of same-day processing
- Your MOTS-c peptide will arrive in cold-chain packaging with full COA documentation
We ship to the USA, Canada, United Kingdom, Europe, and Australia.
Buy MOTS-c Peptide and Stack With These Research Compounds
Researchers who buy MOTS-c peptide from Peptide Steroids frequently investigate these complementary mitochondrial and metabolic research compounds:
- Buy NAD+ Online The essential mitochondrial coenzyme that works synergistically with MOTS-c in bioenergetics and sirtuin activation research
- Buy SS-31 Peptide Mitochondria-targeted tetrapeptide for cardiolipin binding and electron transport chain optimization
- Buy Epithalon Telomerase-activating tetrapeptide studied alongside MOTS-c in longevity research protocols
- Buy Humanin Peptide Complementary mitochondria-derived peptide for cytoprotection and neuroprotection research
- Buy GHK-Cu Peptide Copper tripeptide for tissue remodeling and anti-inflammatory gene expression studied alongside MOTS-c
FAQ Buy MOTS-c Peptide
Q: Where is the best place to buy MOTS-c peptide online?
A: The best place to buy MOTS-c peptide online is Peptide Steroids. We offer research-grade MOTS-c peptide at 99%+ purity with verified third-party Certificates of Analysis, multiple vial sizes from 5mg to 50mg, cold-chain shipping, comprehensive dosing documentation, and dedicated scientific support from our research team.
Q: What is MOTS-c peptide used for in research?
A: Researchers buy MOTS-c peptide to study its roles as a mitochondria-derived metabolic regulator. Primary research applications include insulin sensitivity and glucose homeostasis, exercise mimetic effects in aged animal models, obesity and adipose tissue metabolism, skeletal muscle preservation and sarcopenia, bone health and osteoporosis, inflammatory regulation via NF-kB suppression, longevity and healthspan extension, and mitochondrial-nuclear communication via stress-activated nuclear translocation.
Q: What is the correct MOTS-c peptide dosing protocol for metabolic research?
A: Published MOTS-c peptide dosing for metabolic research in rodent models ranges from 0.5 mg/kg for acute AMPK activation studies to 15 mg/kg/day for chronic insulin resistance correction protocols. The most commonly cited dosing in the foundational Lee et al. 2015 study was 15 mg/kg/day administered intraperitoneally for 14 days in insulin-resistant mouse models. For aging and physical performance research, published dosing of 5 mg/kg administered 3 times weekly via subcutaneous injection over 8 weeks has demonstrated significant restoration of physical performance in aged mouse models. Peptide Steroids provides full dosing reference documentation compiled from published literature with every order.
Q: How does MOTS-c peptide differ from other mitochondria-derived peptides?
A: MOTS-c peptide is uniquely encoded within the 12S rRNA gene of mitochondrial DNA. Unlike Humanin, which is primarily studied for cytoprotection and neuroprotection, MOTS-c is characterized by its potent metabolic regulatory activity, strong AMPK activation, ability to translocate into the cell nucleus under metabolic stress, and its dramatic rise in circulation during physical exercise. When researchers buy MOTS-c peptide vs Humanin, the choice depends on whether the primary research focus is metabolic regulation versus cytoprotective biology.
Q: How should I store MOTS-c peptide after I buy MOTS-c peptide?
A: Store unreconstituted MOTS-c peptide at -20°C in a dry environment protected from direct light and moisture. After reconstitution with bacteriostatic water or sterile water for injection, store the solution at 2-8°C and use within 21 days to maintain full biological activity and peptide structural integrity. Always label reconstituted vials with the preparation date and concentration.
Q: Is it legal to buy MOTS-c peptide?
A: Yes, it is legal to buy MOTS-c peptide for legitimate laboratory research purposes in most countries. MOTS-c peptide is classified as a research chemical and is not approved by the FDA for human therapeutic use. Peptide Steroids sells MOTS-c peptide strictly for research and laboratory applications with complete documentation to support your scientific protocols.
Additional information
| Strength | 10mg, 40mg |
|---|
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